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Behavioral Neuroscience Projects

New technologies in cognitive phenotyping

Behavioral Neuroscience Projects

Contacts: Valter Tucci (Team Leader).

The field of cognitive phenotyping needs to evolve rapidly in order to bridge the "post-genomic-gap" between genomics and phenomics.

Last Updated on Tuesday, 17 April 2012 16:27

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Genetic basis of behaviour: timing phenotypes

Behavioral Neuroscience Projects

Contacts: Valter Tucci (Team Leader).

The availability of animal models (eg. in mouse genetics) which carry mutations that affect targeted traits, represents a unique resource for functional studies and also provides perfect models for hypothesis-driven experiments. This project aims to screen for novel behavioural mutants but also to characterise cognitive processes in mutant models for synaptic plasticity and timing abnormalities.

 

Last Updated on Tuesday, 17 April 2012 16:26

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Genetic and epigenetic mechanisms that regulate sleep and cognition

Behavioral Neuroscience Projects

Contacts: Valter Tucci (Team Leader).

In mammals the identification of the three main states, wakefulness, NREM and REM sleep, has been widely documented.

 

However, no clear explanation has been offered as to why we have different sleep states. Data from experimental and clinical studies suggest that both NREM and REM sleep may be regulated by separate sets of genes. Some of these genes may be imprinted. For example, Prader-Willi syndrome and Angelman syndrome are neurodevelopmental syndromes that exhibit opposite imprinting profiles and, interestingly, opposite sleep disturbances.

Last Updated on Tuesday, 17 April 2012 16:26

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